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刘国运


刘国运


副教授 硕士生导师,博士

电话15063505132

出生年月1985-03-03

研究方向:主要研究领域是化学生物学和药物化学。目前的研究兴趣和方向集中在(1)多靶点抗肿瘤药物的设计、合成及其相关机制研究(2)小分子天然产物导向的抗癌药物的合成及其活性机制评价。

毕业院校:兰州大学

研究工作简历

2012年毕业于兰州大学化学化工学院;201210月至201412月于复旦大学澳门老牌娱乐官网入口下载药学流动站进行博士后研究工作;201412月进入澳门老牌娱乐官网入口下载工作;主持或参与多项教研项目,发表论文近20篇;获聊城大学优秀自然科学成果二等奖1项。

教研项目 :

1. 基于多靶点策略的HDAC抑制剂的设计、合成及其机制研究,聊城大学博士启动基金, 主持;

2. 应用型人才培养模式下《新药设计与开发》课程教学改革探索(培育),主持;

3. 基于提高代谢稳定性策略的白藜芦醇类抗衰老药物的研发(ZR2018LH022),山东省自然科学基金联合专项,第二位;

4. 国家高技术研究发展计划(863计划,No.2013AA092903)项目,参与。

5. 国家自然科学基金“促氧化剂介导的癌预防活性和机制研究”(311006072012-2014年,参与。

6. 国家自然科学基金青年基金“生物抗氧化剂的结构修饰及其诱导2相代谢酶的结构基础和机制研究”(211721012012-2015年,参与。

发表论文、专利及获奖情况:

1. Hua-Lei Zhang, Xiao-Lu Ren, Wen-Hua Yang, Yu, Xie,Jie Yang, Shang-Jing Guo, Guo-Yun Liu*, Synthesis and Evaluation of Anti-Cancer Activities of Mono-Carbonyl Curcumin Analogs. Latin American Journal of Pharmacy 2018, 37, 958-963.

2. Guo-Yun Liu, Cong-Cong Jia, Pu-Ren Han, Jie Yang*, 3,5-Bis(2-fluorobenzylidene)-4-piperidone induce reactive oxygen species-mediated apoptosis in A549 cells. Medicinal Chemistry Research 2018, 27, 128-136.

3. 刘国运,张琦,薛云霞,杨杰*,含哌啶酮结构单元的姜黄素类似物的合成及诱导癌细胞凋亡活性研究。201826354-359.

4. Guo-Yun Liu, Yong-Zheng Sun, Na Zhou, Xiu-Mei Du, Shang-Jing Guo, Jie Yang*, 3,3’-OH curcumin causes apoptosis in HepG2 cells through ROS-Mediated pathway. European Journal of Medicinal Chemistry 2016, 112, 157-163.

5. Guo-Yun Liu, Qiang Zhai, Jia-Zhuang Chen, Zhuo-Qing Zhang, Jie Yang*, 2,2’-fluorine mono-carbonyl curcumin induce reactive oxygen species-Mediated apoptosis in Human lung cancer NCI-H460 cells. European Journal of Pharmacology, 2016, 786, 161-168.

6. 刘国运,李晓腾,郭尚敬,杨杰*,萘环类姜黄素类似物的合成及其对HepG2细胞株的增殖抑制活性。药学研究, 201635253-256

7. 刘国运,杨杰,郭尚敬,姜黄素导向的抗癌药物的设计、合成及其活性机制研究。2017年聊城大学优秀自然科学成果二等奖。

8. 刘国运,杨杰,郭尚敬,一种共轭体系增大的姜黄素类似物及其制备方法和应用。中国专利,授权号CN105111054B

9. 刘国运,杨杰,3,3’-羟基姜黄素类似物及其制备方法和用途,中国专利,申请号201510640413.0

10. 刘国运,杨杰,一种单羰基姜黄素类似物及其制备方法和用途,中国专利,申请号201610060792.0

11. 杨杰,刘国运,一种含氟基团的白藜芦醇衍生物及制备方法和用途, 中国专利,申请号201710266621.8

12. Guo-Yun Liu, Fang Dai, Yan Li, Wen-Jing Yan, Qi Wang, Jie Yang, Dong-Liang Lu, De-Jun Ding, Dong Lin, and Bo Zhou*, Insights into the importance of exploiting ROS-promoting signaling for designing curcumin-inspired anticancer agents by the case of diarylpentanoids, Free Radical Bio. Med., 2015, 85, 127-137.

13. Wei Zhang, Guoyun Liu, Ruwen Yin, Yingxia Li*, Research Progress of Apratoxin A: A Marine Cyclicdepsipeptide with Significant Anti-cancer Activity, Chin. J. Org. Chem., 2014, 34, 475-484.

14. 刘国运,丁宁,张伟,李英霞*,海洋抗肿瘤环酯肽Apratoxin A类似物的合成,第三届上海市海洋药物青年论文,2014。(优秀论文二等奖)

15. 刘国运,郭颖,李英霞,任素梅,高顶顶,单糖单元为D-甘露糖的皂苷及其制备方法和在制药中的用途,中国专利,2014,申请号:201410662394.7

16. Guo-Yun Liu, Jie Yang,Fang Dai*, Wen-Jing Yan, Qi Wang, Xiu-Zhuang Li, De-Jun Ding, Xiao-Yan Cao and Bo Zhou*, CuII ions and the stilbene-chroman hybrid with a catechol moiety synergistically induced by DNA damage, cell cycle arrest and apoptosis of HepG2 cells: an interesting acid/based-promoted prooxidant reaction, Chem. Eur. J., 2012, 18, 11100-11106.

17. Xiao-Yan Cao, Jie Yang, Fang Dai*, De-Jun Ding, Yan-Fei Kang, Fu Wang, Xiu-Zhuang Li, Guo-Yun Liu, Sha-Sha Yu, Xiao-Ling Jin, Bo Zhou*, Extraordinary radical-scavengers: 4-mercaptostilbenes, Chem. Eur. J.,2012, 18, 5898-5905.

18. De-Jun Ding, Xiao-Yan Cao, Fang Dai, Xiu-Zhuang Li, Guo-Yun Liu, Dong Lin, Xing Fu, Xiao-Ling Jin, Bo Zhou*, Synthesis and antioxidant activity of hydroxylated phenanthrenes as cis-restricted resveratrol analogues, Food Chem., 2012, 135, 1011-1019.

19. Yan-hua Ma, Zhen-yang Zhang, Cui-ling Ren, Guo-yun Liu and Xing-guo Chen*, A novel colorimetric determination of reduced glutathione in A549 cells based on Fe3O4 magnetic nanoparticles as peroxidase mimetics, Analyst, 2012, 137, 485-489.

20. Jie Yang, Guo-Yun Liu, Fang Dai, Xiao-Yan Cao, Yan-Fei Kang, Li-Mei Hu, Jiang-Jiang Tang, Xiu-Zhuang Li, Yan Li, Xiao-Ling Jin*, and Bo Zhou*, Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents, Bioorg. Med. Chem. Lett., 2011, 21, 6420-6425.

21. Jie Yang, Guo-Yun Liu, Dong-Liang Lu, Fang Dai*, Yi-Ping Qian, Xiao-Ling Jin* and Bo Zhou*, Hybrid-increased radical-scavenging activity of reveratrol derivatives by incorporating a chroman moiety of vitamin E,Chem. Eur. J.,2010, 16, 12808-12813.

22. Ya-Jing Shang, Xiao-Ling Jin, Xian-Ling Shang, Jiang-Jiang Tang, Guo-Yun Liu, Fang Dai, Yi-Ping Qian, Gui-Juan Fan, Qiang liu, Bo Zhou*, Antioxidant capacity of curcumin-directed analogues: Structure-activity relationship and influence of microenvironment,Food Chem., 2010, 119, 1435-1442.




















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