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聂少振

聂少振 博士


  email: nieshaozhen@163.com

 

教育与工作经历:

2013.11-至今   澳门老牌娱乐官网入口下载

2013.6- 2013.11深圳市东阳光实业发展有限公司研究院   研发工程师

2008.9 - 2013.6 中山大学澳门老牌娱乐官网入口下载有机化学专业          硕、博士 

2004.9 - 2008.6 聊城大学化学与化工学院化学专业      学士    

 

研究方向:

1):不对称合成及其在手性药物合成中的应用

2):过渡金属催化的碳氢活化反应的研究。

 

参与科研项目情况:

1)、省自然科学基金:含氮杂环化合物Csp3-H键的不对称脱氢偶联反应研究,2014-2016,负责人。

2)、博士启动基金:手性药物合成方法学研究,2013-2016,负责人

3)、国家自然科学基金:叠氮甲酸酯参与的碳-氢插入反应研究,2010-2012,参与人。

4)、国家自然科学基金:基于α-硝基酮的有机催化串联反应研究,2012-2015,参与人。

5)、国家自然科学基金:导向基团介导的金属卡宾的高选择性分子键C-H插入反应研究,2013-2015,参与人。

 

研究论文:

1. Shao-zhen Nie,†,§ Xiang Sun,†,§ Wen-tao Wei,† Xue-jing Zhang,† Ming Yan,*,† and Jian-liang Xiao*,‡. Unprecedented Construction of C=C Double Bonds via Ir-Catalyzed Dehydrogenative and Dehydrative Cross-Couplings. Org. Lett. 2013, 15, 2394-2397.

2. Shao-zhen Nie, Zhi-peng Hu, Yi-ning Xuan, Jin-jia Wang, Xue-ming Li and Ming Yan*, Organocatalytic asymmetric conjugate addition of malonates to 3-nitro-2H-chromenes, Tetrahedron: Asymmetry, 2010, 21, 2055-2059.

3. Yi-ning Xuan, Shao-zhen Nie, Li-ting Dong, Jun-min Zhang, and Ming Yan*, Highly Enantioselective Synthesis of Nitrocyclopropanes via Organocatalytic Conjugate Addition of Bromomalonate toα,β-Unsaturated Nitroalkenes. Org. Lett. Vol. 11, No. 7, 2009, 1583-1586.

4. Wen-tao Wei, Xue-jiao Dong, Shao-zhen Nie, Yan-yan Chen, Xue-jing Zhang, and Ming Yan*,Intramolecular Dehydrative Coupling of Tertiary Amines and Ketones Promoted

by KO‑t‑Bu/DMF: A New Synthesis of Indole Derivatives.Org. Lett., 2013, 15, 6018-6021.

5. Xiang Sun, Yu Hu, Shao-zhen Nie, Yun-yun Yan, Xue-jing Zhang, Ming Yan, Efficient Construction of C=N Double Bonds via Acceptorless Dehydrogenative Coupling, Advanced Synthesis & Catalysis, 2013, 355, 2179-2184.

6. Zhi-peng Hu, Jun-min Zhang, Chun-liang Lou, Jin-jia Wang, Shao-zhen Nie, and Ming Yan*Efficient conjugate addition of carbonyl compounds to 3-nitro-2H-chromenes in the presence of bases, Arkivoc 2010x),17-33.

7. Jin-jia Wang, Jin-hua Lao, Zhi-peng Hu, Rui-Jiong Lu, Shao-zhen Nie, Quan-sheng Du, and Ming Yan*, Organocatalytic asymmetric conjugate addition of cyclic 1,3-dicarbonyl compounds to β,γ-unsaturated α-ketoesters , Arkivoc 2010ix),229-243.

8. Rui-jiong Lu, Yun-yun Yan, Jin-jia Wang, Quan-sheng Du, Shao-zhen Nie, and Ming Yan*Organocatalytic Asymmetric Conjugate Addition and Cascade Acyl Transfer Reaction of α-Nitroketones, J. Org. Chem. 2011, 76, 6230–6239.

9. Rui-jiong Lu, Wei, Wen-tao, Jin-jia Wang, Shao-zhen Nie, Xue-jing Zhang, Ming Yan,* Organocatalytic conjugate addition of alpha-nitroacetates to beta, gamma-unsaturated alpha-keto esters and subsequent decarboxylation: synthesis of optically active delta-nitro-alpha-keto esters. Tetrahedron 2012, 68, 9397-9404.   

10. Jin-jia Wang, Jin-hua Lao, Quan-sheng Du, Shao-zhen Nie, Zhi-peng Hu, Ming Yan*, Enantioselective conjugate addition of ketones to nitroalkenes catalyzed by pyrrolidine-sulfamides. CHIRALITY 2013, 24, 232-238.

11. Nian-hua Luo, Xiang Sun, Yun-yun Yan, Shao-zhen Nie, Ming Yan*, Asymmetric synthesis of O-alkylated tetronic acid derivatives via an organocatalytic Mannich reaction and subsequent intramolecular cyclization.Tetrahedron: Asymmetry.2011, 22, 1536–1541.

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